Are Broad-Spectrum Fluoroquinolones More Likely To Cause Clostridium difficile -Associated Disease?

Are broad-spectrum fluoroquinolones more likely to cause Clostridium difficile-associated disease?

Limited evidence suggests that broad-spectrum fluoroquinolones such as gatifloxacin and moxifloxacin are more likely to cause Clostridium difficile-associated disease than levofloxacin. In a population-based case-control study of outpatients prescribed fluoroquinolones, we found no increased risk of C. difficile-associated disease requiring hospitalization among patients prescribed gatifloxacin...

Clostridium difficile associated disease

Direct gas-liquid chromatography of faecal specimens with isocaproic acid as a marker was used for the rapid diagnosis of Clostridium difficile associated diarrhoeal diseases. Ninety stools were examined and results were compared with conventional culture on selective medium and cytotoxin assay in tissue culture. Using a combined analysis of isocaproic acid and butyric acid peak heights we defi...

Clinical management of Clostridium difficile-associated disease.

The incidence of Clostridium difficile-associated disease (CDAD) and its serious complications (including colectomy and death) have been increasing worldwide. This phenomenon is strongly associated with the appearance of a new "hypervirulent" strain in several countries. More-effective strategies are needed for the prevention and treatment of this entity. This article will review the current ap...

Are angry men more likely to develop cardiovascular disease?

Clinical spectrum & pathogenesis of Clostridium difficile associated diseases.

Clostridium difficile is the major aetiological agent of antibiotic associated diarrhoea and colitis. The majority of hospitalized patients infected by C. difficile are asymptomatic carriers who serve as silent reservoirs for continued C. difficile contamination of the hospital environment. C. difficile associated disease (CDAD) is a serious condition with mortality up to 25 per cent in frail e...